ALEXIS Biochemicals: (-)-Indolactam V

ALX-420-011

Revised 12-Jan-07

(-)-Indolactam V
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKC Activators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-011-C300		300 µg	110.00 USD
ALX-420-011-M001		1 mg	250.00 USD

Product Specification

FORMULA:	C₁₇H₂₃N₃O₂
MW:	301.4
CAS NUMBER:	90365-57-4
RTECS:	UY8547000
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL. MAY BE CARCINOGENIC.
IDENTITY:	May contain traces of (+)-Indolactam V.

Product Description

Moderately potent indolactam activator of protein kinase C (PKC). Increases cytoplasmic mRNAs.

Product Specific Literature References

Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann 75, 866 (1984) Abstract
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC 162, 1207 (1989) Abstract
Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways: C.E. Lee, et al.; Cell Immunol. 146, 171 (1993) Abstract
Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay: H.L. Shieh, et al.; Mol. Carcinogen. 12, 166 (1995) Abstract

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