ALEXIS Biochemicals: (±)-BAY K 8644

ALX-550-213

Revised 06-Jun-08

(±)-BAY K 8644
SYNONYMS	1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]pyridine-3-carboxylic acid methyl ester
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Channels (L-type)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-213-M005		5 mg	80.00 USD
ALX-550-213-M025		25 mg	320.00 USD

Product Specification

FORMULA:	C₁₆H₁₅F₃N₂O₄
MW:	356.3
CAS NUMBER:	93468-89-4
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Potent, direct acting, voltage-sensitive Ca²⁺ channel (L-type) agonist.

Product Specific Literature References

The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels: G. Franckowiak, et al.; Eur. J. Pharmacol. 114, 223 (1985) Abstract
BAY-K-8644, a calcium channel agonist, induces a rise in cytoplasmic free calcium and iodide discharge in thyroid cells: N. Takasu, et al.; BBRC 143, 1107 (1987) Abstract
Goldstein, et al.; Drug Dev. Res. 11, 59 (1987)
Calcium channel ligands: D.J. Triggle & R.A. Janis; Ann. Rev. Pharmacol. Toxicol. 27, 347 (1987) Abstract
1,4-Dihydropyridine activators and antagonists: structural and functional distinctions: D.J. Triggle & D. Rompe; TIPS 10, 507 (1989) Abstract

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