ALEXIS Biochemicals: (+)-Calystegine B2

ALX-350-314

Revised 20-Dec-07

(+)-Calystegine B2
SYNONYMS	(1R,2S,3R,4S,5R)-8-Azabicyclo[3.2.1]octane-1,2,3,4-tetrol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-314-M001		1 mg	90.00 USD
ALX-350-314-M005		5 mg	360.00 USD

Product Specification

FORMULA:	C₇H₁₃NO₄
MW:	175.2
CAS NUMBER:	127414-85-1
SOURCE/HOST:	Isolated from Lycopersicon sp.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Selective glycosidase inhibitor sharing such activity with other hydroxylated nitrogen containing bicyclic compounds like swainsonine (Prod. No. ALX-350-077), castanospermine (Prod. No. ALX-270-160), monocyclic deoxynojirimycin (Prod. No. ALX-580-003) or fagomine. Most abundant form is calystegine B2 occurring in almost all plants displaying calystegines. Inhibitory potency of calystegine B2 is comparable to other alkaloidal glycosidase inhibitors showing K_i values below 1µM.

Product Specific Literature References

Identification of the glycosidase inhibitors swainsonine and calystegine B2 in Weir vine (Ipomoea sp. Q6 [aff. calobra]) and correlation with toxicity: R.J. Molyneux, et al.; J. Nat. Prod. 58, 878 (1995) Abstract
The effects of calystegines isolated from edible fruits and vegetables on mammalian liver glycosidases: N. Asano, et al.; Glycobiology 70, 1085 (1997) Abstract
Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors: M.I. Garcia-Moreno, et al.; J. Org. Chem. 66, 7604 (2001) Abstract
Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium: Y. Scholl, et al.; Phytochemistry 62, 325 (2003) Abstract
Chemistry and biology of calystegines: B. Drager; Nat. Prod. Rep. 21, 211 (2004) Abstract
Calystegines in potatoes with genetically engineered carbohydrate metabolism: U. Richter, et al.; J. Exp. Bot. 58, 1603 (2007) Abstract

ALX-270-160	Castanospermine
ALX-350-077	Swainsonine
ALX-580-003	1-Deoxynojirimycin