ALEXIS Biochemicals: µ-Conotoxin GIIIB

ALX-630-054

Revised 10-Oct-08

µ-Conotoxin GIIIB
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-054-C500		500 µg	790.00 USD

Product Specification

SEQUENCE:	H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH₂ (Disulfide bonds between Cys³-Cys¹⁵, Cys⁴-Cys²⁰and Cys¹⁰-Cys²¹)
FORMULA:	C₁₀₁H₁₇₅N₃₉O₃₀S₇
MW:	2640.2
SOURCE/HOST:	Synthetic. Originally isolated from Conus geographus.
APPEARANCE:	White lyophilized powder.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	POTENT NEUROTOXIN.

Product Description

Neurotoxin. Specific blocker of the skeletal voltage-gated Na⁺channels. Not for sale in U.S.A.

Product Specific Literature References

Conus geographus toxins that discriminate between neuronal and muscle sodium channels: L.J. Cruz, et al.; J. Biol. Chem. 260, 9280 (1985) Abstract; Full Text
Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse: S.J. Hong & C.C. Chang; Br. J. Pharmacol. 97, 934 (1989) Abstract
Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle: M. Kimura, et al.; J. Pharmacol. Exp. Ther. 256, 18 (1991) Abstract
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels: R. Robitaille & M.P. Charlton; J. Neurosci. 12, 297 (1992) Abstract
Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction: S. Kubo, et al.; Pept. Res. 6, 66 (1993) Abstract
Using the deadly mu-conotoxins as probes of voltage-gated sodium channels: R. A. Li & G. F. Tomaselli; Toxicon 44, 117 (2004), (Review) Abstract

Further Categories Containing This Product:

Na+ Channels • Peptides

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.