ALEXIS Biochemicals: (+)-Egenine

ALX-350-362

Revised 26-Mar-08

(+)-Egenine
SYNONYMS	6-(6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,8-dihydrofuro[3,4-E][1,3]benzodioxol-8-ol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-362-M025		25 mg	95.00 USD
ALX-350-362-M100		100 mg	285.00 USD

Product Specification

FORMULA:	C₂₀H₁₉NO₆
MW:	369.4
CAS NUMBER:	6883-44-9
SOURCE/HOST:	Isolated from Fumaria vaillantii or Corydalis decumbens.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in ethyl acetate or chloroform; sparingly soluble in 100% ethanol or ether; practically insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

First phthalideisoquinoline hemiacetal from a natural source. Inhibits Ca²⁺ currents and contractile responses in vitro.

Product Specific Literature References

Egenine: A possible intermediate in phthalideisoquinoline biogenesis: B. Gotzler, et al.; Tetrahedron 39, 577 (1983)
Synthesis of (-)-egenine (decumbensine) by asymmetric carbonyl addition: K.S. Rein & R.E. Gawley; Tetrahedron Lett. 31, 3711 (1990)
Synthesis of phthalide isoquinoline alkaloides (-)-egenine, (-)-corytensine, and (-)-bicuculline by asymmetric carbonyl addition of chiral dipole-stabilized organometallics: K.S. Rein & R.E. Gawley; J. Org. Chem. 56, 1564 (1991)
β-Phenylethylamines and the isoquinoline alkaloids: K.W. Bentley; Natural Prod. Rep. 11, 555 (1994), (Review)
1-Magnesiotetrahydroisoquinolyloxazolines as chiral nucleophiles in stereoselective additions to aldehydes: Auxiliary optimization, asymmetric synthesis of (+)-corlumine, (+)-bicuculline, (+)-egenine, and (+)-corytensine, and preliminary (13)C NMR studies: R.E. Gawley & P. Zhang; J. Org. Chem. 61, 8103 (1996) Abstract
Effects of alkaloids from Corydalis decumbens on contraction and electrophysiology of cardiac myocytes: S. Kadota, et al.; Phytother. Res. 10, 18 (1998)

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Calcium Signalling (Intracellular) Other Products • Alkaloids

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