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ALX-550-064 Revised 07-Oct-08
(±)-Huperzine A
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SYNONYMS (±)-Selagine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-064-M001   1 mg 50.00 USD Add To Cart
ALX-550-064-M005   5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O
MW: 242.3
CAS NUMBER: 120786-18-7
MERCK INDEX: 14: 4755
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in dilute aqueous acids or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
Product Description

Racemic modification of (-)-Huperzine A (Prod. No. ALX-550-065) with acetylcholinesterase inhibitor activity. Has a weaker biological activity than (-)Huperzine A. Neurotoxic.
Product Specific Literature References
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986)
A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989) Abstract
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991) Abstract
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani, et al.; BBRC 184, 719 (1992) Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993)
Huperzine A ameliorates the spatial working memory impairments induced by AF64A: Q.X. Zhi, et al.; NeuroReport 6, 2221 (1995) Abstract
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review) Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006) Abstract
Further Categories Containing This Product:
Acetylcholine Esterase / Related Products • Alkaloids
 
 
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