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ALX-550-306 Revised 09-Nov-07
(±)-Verapamil . hydrochloride
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SYNONYMS 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Channels (L-type)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-306-G001   1 g 24.00 USD Add To Cart
ALX-550-306-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C27H38N2O4 . HCl
MW: 454.6 . 36.5
CAS NUMBER: 152-11-4
MERCK INDEX: 14: 9950
RTECS: YV8320000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Blocks L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines.
Product Specific Literature References
Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle: A. Fleckenstein; Ann. Rev. Pharmacol. 17, 149 (1977) Abstract
alpha-adrenergic antagonists as possible calcium channel inhibitors: D. Atlas & M. Adler; PNAS 78, 1237 (1981) Abstract
Effect of trifluoperazine, compound 48/80, TMB-8 and verapamil on the rate of calmodulin binding to erythrocyte Ca2+-ATPase: O. Scharff & B. Foder; Biochim. Biophys. Acta 772, 29 (1984) Abstract
Participation of intracellular sites in the action of Ca2+ channel blockers: E.J. White & H.F. Bradford; Eur. J. Pharmacol. 130, 243 (1986) Abstract
R. Janis, et al.; Adv. Drug Res. 16, 309 (1987)
Goodman and Gilman's The Pharmacological Basis of Therapeutics, vol. 8; p. 774 (1990)
Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex: D. Piwnica-Worms, et al.; Cancer Res. 53, 977 (1993) Abstract
Effect of high-dose verapamil administration on the Ca2+ channel density in rat cardiac tissue: B.B. Lonsberry, et al.; Pharmacology 49, 23 (1994) Abstract
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res. 14, 1027 (1994) Abstract
Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line: I.B. Shchepotin, et al.; Int. J. Hyperthermia 13, 547 (1997) Abstract
Hyperthermia and verapamil inhibit the growth of human colon cancer xenografts in vivo through apoptosis: I.B. Shchepotin, et al.; Anticancer Res. 17, 2213 (1997) Abstract
Neuron degeneration induced by verapamil and attenuated by EGb761: L. Zhu, et al.; J. Basic Clin. Physiol. Pharmacol. 8, 301 (1997) Abstract
 
 

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