ALEXIS Biochemicals: 1-Azakenpaullone

ALX-270-430

Revised 23-Mar-06

1-Azakenpaullone
SYNONYMS	9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	GSK-3 Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-430-M001		1 mg	95.00 USD
ALX-270-430-M005		5 mg	380.00 USD

Product Specification

FORMULA:	C₁₅H₁₀BrN₃O
MW:	328.2
PURITY:	≥95% (HPLC)
APPEARANCE:	Off-white to tan powder.
SOLUBILITY:	Soluble in DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:	Protect from light.

Product Description

Analog of kenpaullone (Prod. No. ALX-270-274) acting as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀=18nM). Displays ~100-200 fold greater selectivity on
GSK-3β than over CDK1/cyclin B and CDK5/p25 (IC₅₀=2.0µM and 4.2µM, respectively).

Product Specific Literature References

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett. 14, 413 (2004) Abstract
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lett. 15, 823 (2005) Abstract