ALEXIS Biochemicals: 1-Deoxymannojirimycin . hydrochloride

ALX-580-002

Revised 03-Apr-08

1-Deoxymannojirimycin . hydrochloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-580-002-M001		1 mg	26.00 USD
ALX-580-002-M005		5 mg	78.00 USD

Product Specification

FORMULA:	C₆H₁₃NO₄. HCl
MW:	163.2 . 36.5
CAS NUMBER:	84444-90-6
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in water, methanol (warm) or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.

Product Specific Literature References

Inhibitors of oligosaccharide processing: U. Fuhrmann, et al.; Biochim. Biophys. Acta 825, 95 (1985) Abstract
Secretion of high-mannose-type alpha 1-proteinase inhibitor and alpha 1- acid glycoprotein by primary cultures of rat hepatocytes in the presence of the mannosidase I inhibitor 1-deoxymannojirimycin: V. Gross, et al.; Eur. J. Biochem. 150, 41 (1985) Abstract
The use of 1-deoxymannojirimycin to evaluate the role of various alpha- mannosidases in oligosaccharide processing in intact cells: J. Bischoff, et al.; J. Biol. Chem. 261, 4766 (1986) Abstract; Full Text
Effect of retinyl acetate on the assembly of the fibronectin extracellular matrix and the processing of the fibronectin receptor beta subunit of confluent C3H/10T1/2 mouse embryo fibroblasts: S.S. Suzuki & L.H. Piette; J. Cell. Biochem. 51, 181 (1993) Abstract
1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721: Y. Lu, et al.; Biochem. Biophys. Res. Commun. 344, 221 (2006) Abstract

Further Categories Containing This Product:

Glycosidases / Related Products • Alkaloids

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