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ALX-300-006 Revised 03-Jul-06
1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
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SYNONYMS rac-ET-18-OCH3
Edelfosine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-006-M050   50 mg 45.00 USD Add To Cart
ALX-300-006-M250   250 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C27H58NO6P
MW: 523.7
CAS NUMBER: 70641-51-9
RTECS: YK0718000
PURITY: ≥99%
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in chloroform (50mg/ml), 100% ethanol (5mg/ml) or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: MAY BE MUTAGENIC. HARMFUL.
Product Description
Produces strong antitumor and antimetastatic activities. Inhibits phosphatidylinositol specific phospholipase C and protein kinase C (PKC). Induces apoptosis.
Product Specific Literature References
Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3- phosphocholine on MO4 mouse fibrosarcoma cells in vitro: G.A. Storme, et al.; Cancer Res. 45, 351 (1985) Abstract
Cytotoxic ether phospholipids. Different affinities to lysophosphocholine acyltransferases in sensitive and resistant cells: D.B.J. Herrmann & H.A. Neumann; J. Biol. Chem. 261, 7742 (1986) Abstract; Full Text
Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440: K. Oishi, et al.; BBRC 157, 1000 (1988) Abstract
Solubilization of the NADPH-oxidase from bone marrow derived macrophages by dialkylphospholipid and purification by HPLC-anion exchange chromatography: J. Storch & E. Ferber; Biol. Chem. Hoppe-Seyler 369, 403 (1988) Abstract
Molecular dynamics of antitumor ether-linked phospholipids in model membranes: a spin-label study: C.-S. Lai, et al.; BBRC 160, 1189 (1989) Abstract
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells: F. Mollinedo, et al.; Biochem. J. 302, 325 (1994) Abstract
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture: B.B. Lundberg; Anticancer Drug Des. 12, 503 (1997) Abstract
Selective induction of apoptosis in cancer cells by the ether lipid ET- 18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L): F. Mollinedo, et al.; Cancer Res. 57, 1320 (1997) Abstract
The inhibition of cell signaling pathways by antitumor ether lipids: G. Arthur & R. Bittman; Biochim. Biophys. Acta. 1390, 85 (1998) Abstract
Cytotoxic etherphospholipid analogues: D. Berkovic; Gen Pharmacol. 31, 511 (1998) Abstract
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O- methyl-rac-glycero-3-phosphocholine: C. Gajate, et al.; Mol. Pharmacol. 53, 602 (1998) Abstract
The anticancer drug edelfosine is a potent inhibitor of neovascularization in vivo: W.R. Vogler, et al.; Cancer Invest. 16, 549 (1998) Abstract
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling: O. Cuvillier, et al.; Blood 94, 3583 (1999) Abstract
Induction of apoptosis in human mitogen-activated peripheral blood T- lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system: C. Cabaner, et al.; Br. J. Pharmacol. 127, 813 (1999) Abstract
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis: G.A. Ruiter, et al.; Cancer Res. 59, 2457 (1999) Abstract
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis: C. Gajate, et al.; Int. J. Cancer 85, 674 (2000) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract
 
 

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