ALEXIS Biochemicals: 1-Oleoyl-2-acetyl-sn-glycerol

ALX-300-300

Revised 08-Dec-08

1-Oleoyl-2-acetyl-sn-glycerol
SYNONYMS	OAG
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Mono- & Diacylglycerols

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-300-M005		5 mg	62.00 USD
ALX-300-300-M025		25 mg	276.00 USD

Product Specification

FORMULA:	C₂₃H₄₂O₅
MW:	398.6
CAS NUMBER:	86390-77-4
CONCENTRATION:	25mg/ml
PURITY:	≥90%
FORMULATION:	Liquid. Solution in acetonitrile.
SOLUBILITY:	20mg/ml soluble in DMSO or dimethyl formamide; miscible with 100% ethanol; 1.7mg/ml soluble in 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -80°C. Stable for at least 3 months in other organic solvents when stored at -80°C. Use aqueous solutions within 12 hours.

Product Description

In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets.

Product Specific Literature References

Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation: K. Kaibuchi, et al.; Cell Calcium 3, 323 (1982) Abstract
Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase: T. Mori, et al.; J. Biochem. (Tokyo) 91, 427 (1982) Abstract
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine: T. Gilmore & G.S. Martin; Nature 306, 487 (1983) Abstract
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation: K. Kaibuchi, et al.; J. Biol. Chem. 258, 6701 (1983) Abstract; Full Text
A possible role of protein kinase C in signal-induced lysosomal enzyme release: N. Kajikawa, et al.; BBRC 116, 743 (1983) Abstract
B. Michell; TIBS 8, 263 (1983), (Review)
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets: T.J. Rink, et al.; Nature 305, 317 (1983) Abstract
Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels: I. Benz, et al.; J. Membr. Biol. 130, 183 (1992) Abstract
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols: E.W. Haeffner & U. Wittmann; J. Lipid Mediat. 5, 237 (1992) Abstract
New patterns of diacylglycerol metabolism in intact cells: J. Florin-Christensen; Biochem. J. 289, 783 (1993) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice.

Further Categories Containing This Product:

PKC Activators

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