ALEXIS Biochemicals: 1-Oleoyl-sn-glycero-3-lysophosphatidic acid . sodium salt

ALX-300-139

Revised 10-Jul-08

1-Oleoyl-sn-glycero-3-lysophosphatidic acid . sodium salt
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-139-M005		5 mg	77.00 USD

Product Specification

FORMULA:	C₂₁H₄₀O₇P . Na
MW:	435.5 . 23.0
CAS NUMBER:	22556-62-3
PURITY:	≥95%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or PBS, pH 7.2 (8.3mg/ml); sparingly soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

Lysophosphatidic acids exert a wide range of biological activities that include stimulation of cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction and cell motility. Lysophosphatidic acids also induce calcium mobilization in cells via a G-protein coupled receptor. 1-Oleoyl lysophosphatidic acid is the most potent of the lysophosphatidic acids with an EC₅₀ of 0.2nM for calcium mobilization in A431 carcinoma cells. The product was shown to stimulate DNA synthesis in quiescent fibroblasts.

Product Specific Literature References

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin: E.J. van Corven, et al.; Biochem. J. 281, 163 (1992) Abstract
Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis: K. Jalink, et al.; Biochem. J. 307, 609 (1995) Abstract

Further Categories Containing This Product:

Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products

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