ALEXIS Biochemicals: 12-Deoxyphorbol 13-acetate

ALX-445-009

Revised 21-Aug-08

12-Deoxyphorbol 13-acetate
SYNONYMS	Prostratin 13-Acetyl-12-deoxyphorbol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Phorbols / Phorbol Esters

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-445-009-M001		1 mg	80.00 USD
ALX-445-009-M005		5 mg	320.00 USD

Product Specification

FORMULA:	C₂₂H₃₀O₆
MW:	390.5
CAS NUMBER:	60857-08-1
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE CARCINOGENIC. IRRITANT.

Product Description

Protein kinase C (PKC) activator that does not induce tumor formation. Upregulates latent HIV-1 provirus expression and inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle.

Product Specific Literature References

The structure of prostratin: A toxic tetracyclic diterpene ester from Pimelea prostrata.: A.R. Cashmore, et al.; Tetrahedron Lett. 20, 1737 (1976)
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia 33, 1554 (1977) Abstract
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res. 53, 2507 (1993) Abstract
Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem. 279, 42008 (2004) Abstract
Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect. 18, 496 (2005), (Review) Abstract
Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T. L. Sung & A. P. Rice; Retrovirology 3, 66 (2006) Abstract

Further Categories Containing This Product:

Natural Products - Antiviral / anti-HIV Agents • HIV / AIDS / Related Products

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