ALEXIS Biochemicals: 1,2-Dioctanoyl-sn-glycerol

ALX-300-052

Revised 16-Apr-05

1,2-Dioctanoyl-sn-glycerol
SYNONYMS	DOG
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Mono- & Diacylglycerols

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-052-M010		10 mg	30.00 USD
ALX-300-052-M050		50 mg	90.00 USD
ALX-300-052-M100		100 mg	150.00 USD

Product Specification

FORMULA:	C₁₉H₃₆O₅
MW:	344.5
CAS NUMBER:	60514-48-9
PURITY:	≥98%
APPEARANCE:	Clear colorless liquid.
SOLUBILITY:	Soluble in DMSO or chloroform.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	At room temperature DOG is an oil. Due to its instability, keep it cool and dry.

Product Description

Potent activator of protein kinase C (PKC).

Product Specific Literature References

Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C: P.M. Conn, et al.; BBRC 126, 532 (1985) Abstract
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis: R.J. Davis, et al.; J. Biol. Chem. 260, 1562 (1985) Abstract; Full Text
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation: J.G. Ebeling, et al.; PNAS 82, 815 (1985) Abstract
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine: Y.A. Hannun, et al.; J. Biol. Chem. 260, 10039 (1985) Abstract; Full Text
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets: E.G. Lapetina, et al.; J. Biol. Chem. 260, 1358 (1985) Abstract; Full Text

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