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ALX-350-234 Revised 08-Apr-08
12-epi-Scalaradial
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-234-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C27H40O4
MW: 428.6
CAS NUMBER: 53527-28-9
SOURCE/HOST: Isolated from Cacospongia sp.
PURITY: ≥98%
APPEARANCE: Waxy solid.
SOLUBILITY: Soluble in acetic acid, 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of bee venom phospholipase A2 (PLA2). Inhibits Ca2+ mobilization induced by leukotriene B4 (LTB4) and platelet activating factor. Inhibits Ca2+-dependent arachidonic acid release in human neutrophils. Inhibits epidermal growth factor (EGF)-stimulated Akt (protein kinase B; PKB) phosphorylation.
Product Specific Literature References
Two-step inactivation of bee venom phospholipase A2 by scalaradial: M.S. De Carvalho & R.S. Jacobs; Biochem. Pharmacol. 42, 1621 (1991) Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils: J.D. Winkler, et al.; Biochem. Pharmacol. 44, 2055 (1992) Abstract
Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation: L.A. Marshall, et al.; J. Pharmacol. Exp. Ther. 268, 709 (1994) Abstract
Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2: Y. Xie, et al.; J. Pharmacol. Exp. Ther. 314, 1210 (2005) Abstract
Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation: M.C. Monti, et al.; Chembiochem 8, 1585 (2007) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Akt [PKB]/Related Products • Calcium Signalling (Intracellular) Other Products
 
 
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