ALEXIS Biochemicals: 1L-6-Hydroxymethyl-chiro-inositol-2-[(R)-2-O-methyl-3-O-octadecylcarbonate]

ALX-270-292

Revised 09-Feb-05

1L-6-Hydroxymethyl-chiro-inositol-2-[(R)-2-O-methyl-3-O-octadecylcarbonate]
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphoinositide 3-kinase [PI(3)K]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-292-M001		1 mg	85.00 USD
ALX-270-292-M005		5 mg	330.00 USD

Product Specification

FORMULA:	C₃₀H₅₈O₁₀
MW:	578.8
PURITY:	>98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Potent inhibitor of Akt (PKB) (IC₅₀=2.0µM). Weak inhibitor of PI(3)K (phosphoinositide 3-kinase) (IC₅₀=83µM). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC₅₀=2.5µM), HT-29 (IC₅₀=10µM), MCF-7 (IC₅₀=1.2µM) and PC-3 (IC₅₀=2.0µM).

Product Specific Literature References

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth: Y. Hu, et al.; J. Med. Chem. 43, 3045 (2000) Abstract

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