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ALX-550-021 Revised 07-Mar-08
(1S,3R)-ACPD
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SYNONYMS (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-021-M005   5 mg 75.00 USD Add To Cart
ALX-550-021-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 111900-32-4
RTECS: GY4060000
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous base or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by NMR.

Product Description
Active isomer of trans-ACPD (Prod. No. ALX-550-020).
Product Specific Literature References
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate: M.A. Desai & P.J. Conn; Neurosci. Lett. 109, 157 (1990) Abstract
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990) Abstract
Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD: P.C. Pook, et al.; Exp. Physiol. 77, 529 (1992) Abstract
In vitro and in vivo pharmacology of 1S,3R- and 1R,3S-ACPD: evidence for a role of metabotropic glutamate receptors in striatal motor function: D.D. Schoepp; Mol. Neuropharmacol. 2, 33 (1992)
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist: J.W. McDonald, et al.; J. Neurosci. 13, 4445 (1993) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp & P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R- ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists: J.P. Tizzano, et al.; Neurosci. Lett. 162, 12 (1993) Abstract
Metabotropic glutamate receptors: novel targets for drug development: T. Knöpfel, et al.; J. Med. Chem. 38, 1417 (1995) Abstract
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices: G. Lombardi, et al.; Br. J. Pharmacol. 117, 189 (1996) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
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Further Categories Containing This Product:
Excitatory Amino Acids
 
 

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