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ALX-340-036 Revised 18-Jul-08
2-Arachidonoylglycerol
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SYNONYMS 2-AG
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-036-M005   5 mg 121.00 USD Add To Cart
Product Specification
FORMULA: C23H38O4
MW: 378.6
CAS NUMBER: 53847-30-6
CONCENTRATION: 10mg/ml
PURITY: ≥95% (as 9:1 mixture of 2-AG and 1-AG)
FORMULATION: Liquid. Solution in acetonitrile.
SOLUBILITY: 10mg/ml soluble in 100% ethanol or DMSO; 150μg/ml soluble in PBS, pH 7.2.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

Stable for at least 6 months after receipt when stored at -80°C. Keep aqueous solutions on ice and use within 12 hours.

HANDLING: Protect from light and oxygen.

Product Description
Endogenous ligand for the CB1 receptor (CB1: Ki=58.3nM); CB2: Ki>3µM) present in high levels in the CNS.
Product Specific Literature References
A second endogenous cannabinoid that modulates long-term potentiation: N. Stella, et al.; Nature 388, 773 (1997) Abstract
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds: T. Sugiura, et al.; J. Biol. Chem. 274, 2794 (1999) Abstract; Full Text
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity: S. Ben-Shabat, et al.; J. Pharmacol. 353, 23 (1998) Abstract
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors: S.K. Goparaju, et al.; Biochem. Pharmacol. 57, 417 (1999) Abstract
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments: V. Di Marzo, et al.; Lipids 34, S319 (1999), (Review) Abstract
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors: T. Bisogno, et al.; Eur. J. Biochem. 268, 1982 (2001) Abstract
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain: T. Bisogno, et al.; J. Cell Biol. 163, 463 (2003) Abstract
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells: S. Kishimoto, et al.; J. Biochem. (Tokyo) 135, 517 (2004) Abstract
The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein: G.J. Maestroni; FASEB J. 18, 1914 (2004) Abstract; Full Text
New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation: T. Sugiura, et al.; J. Pharmacol. Sci. 96, 367 (2004) Abstract; Full Text
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion: K. Nithipatikom, et al.; Cancer Res. 64, 8826 (2004) Abstract; Full Text
2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells: M. Gokoh, et al.; Biochem. J. 386, 583 (2005) Abstract; Full Text
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells: K. Nithipatikom, et al.; BBRC 332, 1028 (2005) Abstract
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Protic solvents such as ethanol, water etc. tend to enhance the rate of isomerization to 1-AG. It is highly recommended to store the product in acetonitrile until use. To change the solvent, evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice. Use these solutions at once as the long term stability of 2-Arachidonoylglycerol in these solvents is not known.
 
 

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