ALEXIS Biochemicals: 2-Fluoropalmitic acid

ALX-300-132

Revised 04-Feb-05

2-Fluoropalmitic acid
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Fatty Acids

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-132-M001		1 mg	15.00 USD
ALX-300-132-M005		5 mg	60.00 USD

Product Specification

FORMULA:	C₁₆H₃₁FO₂
MW:	274.4
CAS NUMBER:	89270-22-4
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Inhibitor of palmityl-CoA biosynthesis resulting in blockade of protein palmitoylation.

Product Specific Literature References

D,L-alpha-Fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells: R.M. Soltysiak, et al.; Biochim. Biophys. Acta 792, 214 (1984) Abstract
All ras proteins are polyisoprenylated but only some are palmitoylated: J.F. Hancock, et al.; Cell 57, 1167 (1989) Abstract
Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation: N.E. Abraham & A. Veillette; Mol. Cell. Biol. 10, 5197 (1990) Abstract
The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification: M.Y. Degtyarev, et al.; Biochemistry 32, 8057 (1993) Abstract
Lipid modifications of G proteins: alpha subunits are palmitoylated: M.E. Linder, et al.; PNAS 90, 3675 (1993) Abstract
A novel N-terminal motif for palmitoylation of G-protein alpha subunits: M. Parenti, et al.; Biochem. J. 291, 349 (1993) Abstract

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