ALEXIS Biochemicals: 2-Hydroxymyristic acid

ALX-300-131

Revised 04-Feb-05

2-Hydroxymyristic acid
SYNONYMS	2-Hydroxy-tetradecanoic acid
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Fatty Acids

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-131-M025		25 mg	35.00 USD

Product Specification

FORMULA:	C₁₄H₂₈O₃
MW:	244.4
CAS NUMBER:	2507-55-3
PURITY:	≥97%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Selective inhibitor of protein myristoylation in cells, able to distinguish myristoylation from palmitoylation. Metabolic activation appears to be required. Myristoylation takes place on glycine residues at the N-terminus of proteins and provides a strong membrane anchor for the modified proteins, many of which require myristoylation for full activity.

Product Specific Literature References

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation: N. Abraham & A. Veillette; Mol. Cell. Biol. 10, 5197 (1990) Abstract
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase: L.A. Paige, et al.; Biochemistry 29, 10566 (1990) Abstract
The G protein connection: molecular basis of membrane association [published erratum appears in TIBS 17, 177 (1992)]: A.M. Spiegel, et al.; TIBS 16, 338 (1991), (Review) Abstract
Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck: M.J.S. Nadler, et al.; Biochemistry 32, 9250 (1993) Abstract
Reversible palmitoylation of the protein-tyrosine kinase p56lck: L.A. Paige, et al.; J. Biol. Chem. 268, 8669 (1993) Abstract; Full Text
Inhibition of varicella-zoster virus replication by an inhibitor of protein myristoylation: D.R. Harper, et al.; J. Gen. Virol. 74, 1181 (1993) Abstract

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