ALEXIS Biochemicals: 2-Phthalimidino-glutaric acid

ALX-430-097

Revised 29-Jan-05

2-Phthalimidino-glutaric acid
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Reagents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-097-M005		5 mg	60.00 USD
ALX-430-097-M025		25 mg	240.00 USD

Product Specification

FORMULA:	C₁₃H₁₃NO₅
MW:	263.3
PURITY:	≥96%
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Stable analog of thalidomide with increased antitumor (antimetastatic) potency.

Product Specific Literature References

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes: E.P. Sampaio, et al; J. Exp. Med. 173, 699 (1991) Abstract
The effect of thalidomide on experimental tumors and metastases: A.I. Minchinton, et al.; Anticancer Drugs 7, 339 (1996) Abstract
Thalidomide. A surprising recovery: D. Stirling, et al.; J. Am. Pharm. Assoc. NS37, 306 (1997) Abstract
Inhibition of angiogenesis by thalidomide requires metabolic activation, which is species-dependent: K.S. Bauer, et al.; Biochem Pharmacol 55, 1827 (1998) Abstract
Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis: J.H. Shah, et al.; J. Med. Chem. 42, 3014 (1999) Abstract
Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide: R. Shimazawa, et al.; Biol. Pharm. Bull. 22, 224 (1999) Abstract

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