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ALX-270-005 Revised 07-Sep-06
2,4-Diamino-6-hydroxypyrimidine
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SYNONYMS DAHP
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-005-M250   250 mg 25.00 USD Add To Cart
ALX-270-005-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C4H6N4O
MW: 126.2
CAS NUMBER: 56-06-4
MERCK INDEX: 14: 2981
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol; slightly soluble in hot water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective inhibitor of GTP cyclohydrolase I, which is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis. Thus it suppresses the activity of nitric oxide synthase (NOS).
Product Specific Literature References
Biopterin. III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin: E.M. Gal, et al.; Neurochem. Res. 3, 69 (1978) Abstract
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts: G. Werner-Felmayer, et al.; J. Exp. Med. 172, 1599 (1990) Abstract
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine- induced nitric oxide generation by vascular smooth muscle: S.S. Gross & R. Levi; J. Biol. Chem. 267, 25722 (1992) Abstract; Full Text
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP: G. Werner-Felmayer, et al.; J. Biol. Chem. 268, 1842 (1993) Abstract; Full Text
2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages: Y.J. Sung, et al.; Int. J. Immunopharmacol. 16, 101 (1994) Abstract
2,4-Diamino-6-hydroxypyrimidine, an inhibitor of tetrahydrobiopterin synthesis, downregulates the expression of iNOS protein and mRNA in primary murine macrophages: C. Bogdan, et al.; FEBS Lett. 363, 69 (1995) Abstract
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein: L. Xie, et al.; J. Biol. Chem. 273, 21091 (1998) Abstract; Full Text
Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats: H.Y. Li, et al.; Crit. Care Med. 30, 2520 (2002) Abstract
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Abstract; Full Text
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein: M.A. Kolinsky & S.S. Gross; J. Biol. Chem. 279, 40677 (2004) Abstract; Full Text
 
 

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