ALEXIS Biochemicals: 2,4-Diethylpyridine dicarboxylate

ALX-270-372

Revised 08-Jul-08

2,4-Diethylpyridine dicarboxylate
SYNONYMS	2,4-DPD 2,4-Pyridinedicarboxylic acid diethyl ester
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Hypoxia-inducible Factor [HIF] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-372-M010		10 mg	23.00 USD
ALX-270-372-M025		25 mg	53.00 USD
ALX-270-372-M100		100 mg	177.00 USD

Product Specification

FORMULA:	C₁₁H₁₃NO₄
MW:	223.2
CAS NUMBER:	41438-38-4
CONCENTRATION:	50mg/ml
PURITY:	≥98%
FORMULATION:	Liquid. Solution in ethanol.
SOLUBILITY:	Soluble in 100% ethanol (50mg/ml), DMSO (20mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (1mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at –20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

2,4-DPD is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme HIF prolyl hydroxylase (HIF-PH), which destructs HIF-1α when hydroxylated at a specific proline residue (P564). 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.

Product Specific Literature References

Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans: L. Friedman, et al.; PNAS 97, 4736 (2000) Abstract; Full Text
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing: M. Ivan, et al.; Science 292, 464 (2001) Abstract
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
A conserved family of prolyl-4-hydroxylases that modify HIF: R.K. Bruick & S.L. McKnight; Science 294, 1337 (2001) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.

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