ALEXIS Biochemicals: 2',5'-Dideoxyadenosine

ALX-480-049

Revised 03-Jun-08

2',5'-Dideoxyadenosine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Adenosine Derivatives Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-049-M001		1 mg	30.00 USD
ALX-480-049-M005		5 mg	90.00 USD

Product Specification

FORMULA:	C₁₀H₁₃N₅O₂
MW:	235.2
CAS NUMBER:	6698-26-6
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions are stable for up to 3 months when stored at -20°C.

Product Description

Cell permeable inhibitor of adenylate cyclase (ID₅₀=250µM [1]; inhibition also reported at 1mM [2]). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells [6].

Product Specific Literature References

[1] Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose- modified adenosine analogs: S.T. Holgate, et al.; PNAS 77, 6800 (1980) Abstract
[2] Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni, et al.; J. Pharmacol. Exp. Ther. 259, 508 (1991) Abstract
[3] Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa, et al.; Digestion 54, 135 (1993) Abstract
[4] Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol. 25, 331 (1993) Abstract
[5] Erythroid differentiation and growth inhibition of K562 cells by 2',5'-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa, et al.; Leuk. Res. 19, 749 (1995) Abstract

Further Categories Containing This Product:

Adenylyl Cyclase Inhibitors • Antiviral Agents Other Products

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