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ALX-550-178 Revised 10-Feb-05
(2R,4R)-APDC
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SYNONYMS LY-314,593
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-178-M001   1 mg 70.00 USD Add To Cart
ALX-550-178-M005   5 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C6H10N2O4
MW: 174.2
CAS NUMBER: 169209-63-6
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective agonist for group II mGluRs.
Product Specific Literature References
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate: D.D. Schoepp, et al.; Neuropharmacology 34, 843 (1995) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase: J.A. Monn, et al.; J. Med. Chem. 39, 2990 (1996) Abstract
Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol. 123, 581 (1998) Abstract
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol. 356, 271 (1998) Abstract
Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate: T.E. Salt & J.P. Turner; Exp. Brain Res. 121, 181 (1998) Abstract
Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats: P.J. Atwell, et al.; Brain Res. 787, 286 (1998) Abstract
Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex: C.J. Beaver, et al.; J. Neurophysiol. 82, 86 (1999) Abstract
D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 

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