ALEXIS Biochemicals: 3-(3,5-Di-tert-butyl-4-hydroxybenzylidenyl)indolin-2-one

ALX-270-364

Revised 03-Mar-05

3-(3,5-Di-tert-butyl-4-hydroxybenzylidenyl)indolin-2-one
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Tyrosine Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-364-M001		1 mg	50.00 USD
ALX-270-364-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₂₃H₂₇NO₂
MW:	349.5
CAS NUMBER:	40526-64-5
SOURCE/HOST:	Synthetic.
PURITY:	≥97% (¹H-NMR, HPLC)
APPEARANCE:	Yellow crystals.
SOLUBILITY:	Soluble in DMSO (35mg/ml) or methanol (2.5mg/ml). Sparingly soluble in aqueous buffers (25µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
HANDLING:	Protect from light. Keep cool and dry.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR, IR, ESI-MS and UV.

Product Description

Receptor tyrosine kinase (RTK) inhibitor. Inhibits FLK-1 RTK (IC₅₀~8µM) and EGF RTK. Consists of the E- and Z-isomers [1].

Product Specific Literature References

[1] Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998) Abstract

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