ALEXIS Biochemicals: 3-(4-Isopropylbenzylidenyl)indolin-2-one

ALX-270-362

Revised 04-Feb-05

3-(4-Isopropylbenzylidenyl)indolin-2-one
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Tyrosine Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-362-M001		1 mg	50.00 USD
ALX-270-362-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₈H₁₇NO
MW:	263.4
CAS NUMBER:	186611-55-2
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (¹H-NMR, HPLC)
APPEARANCE:	Yellow crystals.
SOLUBILITY:	Soluble in DMSO (>80mg/ml) or methanol (8mg/ml). Sparingly soluble in aqueous buffers (25µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
HANDLING:	Keep cool and dry. Protect from light.
IDENTITY:	Indentity determined by ¹H-NMR, ¹³C-NMR, IR, ESI-MS and UV.

Product Description

Non-selective inhibitor of receptor tyrosine kinases (RTKs). Inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC₅₀ ~5-25µM) [1]. Consists primarily of the E-isomer; contains ~5% of the Z-isomer [1].

Product Specific Literature References

[1] Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998) Abstract

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