ALEXIS Biochemicals: 3-(4-Phenoxyphenylsulfonyl)propylthiirane

ALX-270-337

Revised 04-Mar-05

3-(4-Phenoxyphenylsulfonyl)propylthiirane
SYNONYMS	MMP-2/MMP-9 Inhibitor
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	MMP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-337-M005		5 mg	50.00 USD
ALX-270-337-M025		25 mg	190.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₃S₂
MW:	306.4
PURITY:	≥98%
APPEARANCE:	White crystalline solid.
SOLUBILITY:	Soluble in DMSO, chloroform, acetone, methanol and other organic solvents.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent and selective inhibitor of matrix metalloproteinases 2 and 9.

Product Specific Literature References

Potent and selective mechanism-based inhibition of Gelatinases: S. Brown, et al.; JACS 122, 6799 (2000)
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2: M. Toth, et al.; J. Biol. Chem. 275, 41415 (2000) Abstract; Full Text
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme: O. Kleifeld, et al.; J. Biol. Chem. 276, 17125 (2001) Abstract; Full Text

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