ALEXIS Biochemicals: 3-(4-Pyridyl)-1H-indole

ALX-270-429

Revised 11-Oct-06

3-(4-Pyridyl)-1H-indole
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Rho-associated Protein Kinases [ROCK] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-429-M005		5 mg	40.00 USD

Product Specification

FORMULA:	C₁₃H₁₀N₂
MW:	194.2
CAS NUMBER:	7272-84-6
PURITY:	≥98% (TLC)
APPEARANCE:	Off-white to beige solid.
SOLUBILITY:	Soluble in DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:	Protect from light.

Product Description

A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC₅₀=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632 (Prod. No. ALX-270-333).

Product Specific Literature References

Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor: J.C. Yarrow, et al.; Chem. Biol. 12, 385 (2005) Abstract
Scratch n’ screen for inhibitors of cell migration: J. Soderholm & R. Heald; Chem. Biol. 12, 263 (2005) Abstract

Related Products

ALX-270-333

Y-27632 . dihydrochloride

Further Categories Containing This Product:

Protein Kinase Inhibitors Other Products

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