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ALX-270-044 Revised 20-Oct-08
3-Aminobenzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-044-G001   1 g 50.00 USD Add To Cart
ALX-270-044-G005   5 g 190.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O
MW: 136.2
CAS NUMBER: 3544-24-9
RTECS: CU8992000
PURITY: ≥97%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. Apoptosis inhibitor.
Product Specific Literature References
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC 179, 1225 (1991) Abstract
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994) Abstract
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994) Abstract
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995) Abstract
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995) Abstract
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • DNA Repair Other Products
 
 
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