ALEXIS Biochemicals: 3-Bromo-7-nitroindazole

ALX-270-009

Revised 03-Jul-07

3-Bromo-7-nitroindazole
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-009-M005		5 mg	20.00 USD
ALX-270-009-M025		25 mg	40.00 USD
ALX-270-009-M050		50 mg	70.00 USD

Product Specification

FORMULA:	C₇H₄BrN₃O₂
MW:	242.0
CAS NUMBER:	74209-34-0
PURITY:	≥98%
APPEARANCE:	Yellowish solid.
SOLUBILITY:	Soluble in DMSO, methanol or 100% ethanol; also soluble in water containing 10% DMSO or in a 50:50 mixture of water:DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Potent inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). More potent than 7-nitroindazole (Prod. No. ALX-270-004).

Product Specific Literature References

7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase: P.A. Bland-Ward & P.K. Moore; Life Sci. 57, PL131 (1995) Abstract
Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro: J. Wu, et al.; Neuroscience 78, 393 (1997) Abstract
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy: D.B. Vaupel, et al.; Eur. J. Pharmacol. 324, 11 (1997) Abstract
3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles: S.C. Gammie, et al.; Brain Res. 870, 80 (2000) Abstract
Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism: C.S. Raman, et al.; Biochemistry 40, 13448 (2001) Abstract
Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat: M. Cavas & J.F. Navarro; Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 56 (2006) Abstract

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