ALEXIS Biochemicals: 4-Oxo-2-nonenal

ALX-270-407

Revised 24-Jul-08

4-Oxo-2-nonenal
SYNONYMS	4-ONE
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Lipid Peroxidation

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-407-M001		1 mg	108.00 USD
ALX-270-407-M005		5 mg	483.00 USD

Product Specification

FORMULA:	C₉H₁₄O₂
MW:	154.2
CAS NUMBER:	103560-62-9
CONCENTRATION:	10mg/ml
PURITY:	≥98%
FORMULATION:	Liquid. Solution in methyl acetate.
SOLUBILITY:	50mg/ml soluble in 100% ethanol, dimethyl formamide or DMSO; sparingly soluble in PBS, pH 7.2 (0.5mg/ml).
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -80°C. Keep aqueous solutions on ice and use within 12 hours.

Product Description

Lipid peroxidation product. Modifies histidine and lysine residues in proteins and causes protein cross-linking, modifies 2'-deoxyguanosine, and implicates lipid peroxidation in mutagenesis and carcinogenesis.

Product Specific Literature References

Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation: D. Rindgen, et al.; Chem. Res. Toxicol. 12, 1195 (1999) Abstract
Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation: S.H. Lee, et al.; Chem. Res. Toxicol. 13, 698 (2000) Abstract
Aldehydic lipid peroxidation products derived from linoleic acid: P. Spiteller, et al.; Biochem. Biophys. Acta 1531, 188 (2001) Abstract
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal: Z. Liu, et al.; Chem. Res. Toxicol. 16, 901 (2003) Abstract
Model studies on protein side chain modification by 4-oxo-2-nonenal: W.H. Zhang, et al.; Chem. Res Toxicol. 16, 512 (2003) Abstract
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation: J.D. West, et al.; Chem. Res. Toxicol. 17, 453 (2004) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments.

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