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ALX-445-006 Revised 03-Dec-07
4α-Phorbol 12,13-didecanoate
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SYNONYMS 4α-PDD
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Phorbols / Phorbol Esters
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-445-006-M001   1 mg 35.00 USD Add To Cart
ALX-445-006-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C40H64O8
MW: 672.9
CAS NUMBER: 27536-56-7
PURITY: ≥98% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.
HANDLING: Protect from light.
HAZARD: HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.

Product Description
Activator of TRPV4. Negative control for phorbol 12,13-didecanoate (PDD) (Prod. No. ALX-445-002).
Product Specific Literature References
TRPV4 calcium entry channel: a paradigm for gating diversity: B. Nilius, et al.; Am. J. Physiol. Cell Physiol. 286, C195 (2004) Abstract
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives: H. Watanabe, et al.; J. Biol. Chem. 277, 13569 (2002) Abstract
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