ALEXIS Biochemicals: 5-Iodo-indirubin-3'-monoxime

ALX-270-424

Revised 13-Feb-07

5-Iodo-indirubin-3'-monoxime
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-424-M001		1 mg	90.00 USD

Product Specification

FORMULA:	C₁₆H₁₀IN₃O₂
MW:	403.2
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	Dark red solid.
SOLUBILITY:	Soluble in DMSO (1M).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Potent inhibitor of GSK-3β (IC₅₀=9nM). Also inhibits CDK1/cyclin B (IC₅₀=25nM) and CDK5/p25 (IC₅₀=20nM) by binding to the ATP-binding pocket.

Product Specific Literature References

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001) Abstract; Full Text

Related Products

ALX-270-271	Indirubin-3'-monoxime
ALX-270-361	Indirubin
ALX-270-296	Indirubin-5-sulfonic acid . sodium salt
ALX-430-149	7BIO
ALX-430-156	6BIO
ALX-430-157	Me-7BIO

Further Categories Containing This Product:

GSK-3 Inhibitors

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.