ALEXIS Biochemicals: 5-Nitro-2-(3'-phenylpropyl-amino)benzoic acid

ALX-550-279

Revised 13-May-05

5-Nitro-2-(3'-phenylpropyl-amino)benzoic acid
SYNONYMS	NPPB
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Cl- Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-279-M005		5 mg	20.00 USD
ALX-550-279-M010		10 mg	45.00 USD
ALX-550-279-M025		25 mg	90.00 USD

Product Specification

FORMULA:	C₁₆H₁₆N₂O₄
MW:	300.3
CAS NUMBER:	107254-86-4
APPEARANCE:	Light yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

High-potency Cl^- channel blocker. Also inhibits cyclooxygenase (COX).

Product Specific Literature References

Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship: P. Wangemann, et al.; Pfluegers Arch. 407, S128 (1986) Abstract
Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels: W. Breuer & K.L. Skorecki; BBRC 163, 398 (1989) Abstract
Actions of the Cl- channel blocker NPPB on absorptive and secretory transport processes of Na+ and Cl- in rat descending colon: M. Diener & W. Rummel; Acta Physiol. Scand. 137, 215 (1989) Abstract
Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line: D.J. Keeling, et al.; Biochim. Biophys. Acta 1115, 42 (1991) Abstract
Different types of blockers of the intermediate-conductance outwardly rectifying chloride channel in epithelia: M. Tilmann, et al.; Pfluegers Arch. 418, 556 (1991) Abstract

Further Categories Containing This Product:

COX Inhibitors

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