ALEXIS Biochemicals: 5-[(S)-(-)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin

ALX-270-374

Revised 08-Dec-04

5-[(S)-(-)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
SYNONYMS	Caspase-7 Inhibitor
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-374-M001		1 mg	120.00 USD

Product Specification

FORMULA:	C₁₄H₁₆N₂O₅S
MW:	324.4
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or methanol.
HANDLING:	Packaged under inert gas. Protect from light.

Product Description

Potent, reversible, non-peptide inhibitor of caspase-3 (K_i=60nm), caspase-7 (K_i=170nM) and caspase-9 (K_i=3.1µM).

Product Specific Literature References

Potent and selective nonpeptide inhibitors of caspases 3 and 7: D. Lee, et al.; J. Med. Chem. 44, 2015 (2001) Abstract
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality: D. Lee, et al.; J. Biol. Chem. 275, 16007 (2000) Abstract

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