ALEXIS Biochemicals: 5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole

ALX-270-095

Revised 07-May-08

5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole
SYNONYMS	DRB 5,6-Dichlorobenzimidazole riboside
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Adenosine Derivatives Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-095-M005		5 mg	20.00 USD
ALX-270-095-M025		25 mg	70.00 USD

Product Specification

FORMULA:	C₁₂H₁₂Cl₂N₂O₄
MW:	319.1
CAS NUMBER:	53-85-0
RTECS:	DD7310000
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO (100mM) or dimethyl formamide (100mM).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:	Identity determined by ¹H-NMR, MS and UV.

Product Description

Selective casein kinase II inhibitor. Inhibitor of RNA synthesis in eukaryotic cells.

Product Specific Literature References

Halobenzimidazole ribosides and RNA synthesis of cells and viruses: I. Tamm & P. Sehgal; Adv. Virus Res. 22, 187 (1978) Abstract
Mechanism of action of 5,6-dichloro-1-beta-D- ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery: B. Mittleman, et al.; J. Mol. Biol. 165, 461 (1983) Abstract
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription: R. Zandomeni, et al.; J. Mol. Biol. 167, 561 (1983) Abstract
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1- beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription: R. Zandomeni, et al.; J. Biol. Chem. 261, 3414 (1986) Abstract; Full Text
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6- dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB): C.E. Farin & L. Yang; Mol. Reprod. Dev. 37, 284 (1994) Abstract

Further Categories Containing This Product:

Casein Kinase Inhibitors

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