ALEXIS Biochemicals: 5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt

ALX-480-047

Revised 23-Jul-08

5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS	Sp-5,6-DCl-cBIMPS . Na 5,6-DCI-cBIMPS . Na, Sp-Isomer
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Other Cyclic Nucleotides

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-047-C100		100 µg	30.00 USD
ALX-480-047-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₁₂H₁₀Cl₂N₂O₅PS . Na
MW:	396.2 . 23.0
CAS NUMBER:	120912-54-1
PURITY:	≥99%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as PBS (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) and Na₂HPO₄ (pH 7.0; 2.8 mM).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent, specific and site selective activator of cAMP-dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian phosphodiesterases type I and III and only extremely slowly hydrolyzed by type II. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. ALX-480-045) or 8-CPT-cAMP (Prod. No. ALX-480-030) in terms of metabolic stability, membrane permeability and potency.

Product Specific Literature References

Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg, et al.; Biochem J. 279, 521 (1991) Abstract

Further Categories Containing This Product:

PKA Activators

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