ALEXIS Biochemicals: 5,7-Dichlorokynurenic acid . sodium salt

ALX-550-043

Revised 15-May-03

5,7-Dichlorokynurenic acid . sodium salt
SYNONYMS	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid . Na
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	NMDA Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-043-M005		5 mg	25.00 USD
ALX-550-043-M025		25 mg	90.00 USD

Product Specification

FORMULA:	C₁₀H₅Cl₂NO₃.Na
MW:	258.1 . 23.0
CAS NUMBER:	131123-76-7
PURITY:	≥98%
APPEARANCE:	Light yellow solid.
SOLUBILITY:	Soluble in DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Potent antagonist at the glycine site of the NMDA receptor.

Product Specific Literature References

Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site: B.M. Baron, et al.; Mol. Pharmacol. 38, 554 (1990) Abstract
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors: D. McNamara, et al.; Neurosci. Lett. 120, 17 (1990) Abstract
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate: P.D. Leeson, et al.; J. Med. Chem. 34, 1243 (1991) Abstract

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