ALEXIS Biochemicals: 6BIO

ALX-430-156

Revised 21-Apr-08

6BIO
SYNONYMS	(2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Non-apoptotic Cell Death/Necrosis

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-156-M001		1 mg	40.00 USD

Product Specification

FORMULA:	C₁₆H₁₀BrN₃O₂
MW:	356.2
CAS NUMBER:	667463-62-9
PURITY:	≥98%
APPEARANCE:	Dark red solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β).

Product Specific Literature References

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract

ALX-270-271	Indirubin-3'-monoxime
ALX-270-296	Indirubin-5-sulfonic acid . sodium salt
ALX-270-361	Indirubin
ALX-270-424	5-Iodo-indirubin-3'-monoxime