ALEXIS Biochemicals: 7,7-Dimethyleicosadienoic acid

ALX-340-008

Revised 22-May-07

7,7-Dimethyleicosadienoic acid
SYNONYMS	DEDA
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PLA2 Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-008-M010		10 mg	120.00 USD

Product Specification

FORMULA:	C₂₂H₄₀O₂
MW:	336.6
CAS NUMBER:	89560-01-0
PURITY:	≥99%
APPEARANCE:	Colorless oil.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions are stable for up to 6 months when stored at –20°C.

Product Description

Potent inhibitor of snake venom phospholipase A₂(PLA₂) and weak inhibitor of 5-lipoxygenase. Inhibits human recombinant synovial phospholipase A₂(sPLA₂)selectively over cytosolic phospholipase A₂(cPLA₂).

Product Specific Literature References

Analogs of arachidonic acid methylated at C-7 and C-10 as inhibitors of leukotriene biosynthesis: N. Cohen, et al.; Prostaglandins 27, 553 (1984) Abstract
A.F. Welton, et al.; Prostaglandins 28, 649 (1984)
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p- bromophenacyl bromide: M.D. Lister, et al.; J. Biol. Chem. 264, 8520 (1989) Abstract; Full Text
Effect of the phospholipase A2 inhibitors quinacrine and 7,7- dimethyleicosadienoic acid in isolated globally ischemic rat hearts: C.A. Sargent, et al.; J. Pharmacol. Exp. Ther. 262, 1161 (1992) Abstract
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions 39, C39 (1993) Abstract

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