ALEXIS Biochemicals: 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt

ALX-480-030

Revised 07-Jun-06

8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS	8-pCPT-cAMP . Na
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cAMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-030-M010		10 mg	25.00 USD
ALX-480-030-M025		25 mg	50.00 USD

Product Specification

FORMULA:	C₁₆H₁₄ClN₅O₆PS . Na
MW:	470.8 . 23.0
CAS NUMBER:	93882-12-3
PURITY:	≥99%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.

Product Description

Lipophilic, membrane permeable activator of both cAMP- and cGMP-dependent protein kinases (PKA, PKG). More potent than cAMP and more resistant to phosphodiesterases, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCl-cBIMPS (Prod. No. ALX-480-047) is a recommended.

Product Specific Literature References

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor: R.E. Rydel & L.A. Greene; PNAS 85, 1257 (1988) Abstract
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs: D. Ogreid, et al.; Eur. J. Biochem. 181, 19 (1989) Abstract
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA): B.J. Connolly, et al.; Biochem. Pharmacol. 44, 2303 (1992) Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system: R.V. Schillace, et al.; J. Immunol. 174, 6847 (2005) Abstract; Full Text

Further Categories Containing This Product:

PKG Activators • PKA Activators

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