ALEXIS Biochemicals: 8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . triethylammonium salt

ALX-480-031

Revised 08-Oct-08

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . triethylammonium salt
SYNONYMS	8-pCPT-cGMP . TEA
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cGMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-031-M001		1 mg	42.00 USD
ALX-480-031-M005		5 mg	168.00 USD

Product Specification

FORMULA:	C₁₆H₁₄ClN₅O₇PS . C₆H₁₅N
MW:	486.8 . 101.2
CAS NUMBER:	54364-02-2
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by MS, UV and ¹H-NMR.

Product Description

Selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.

Product Specific Literature References

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para- chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS 89, 1031 (1992) Abstract

Further Categories Containing This Product:

PKG Activators

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