ALEXIS Biochemicals: 8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt (high purity)

ALX-480-032

Revised 03-Feb-05

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt (high purity)
SYNONYMS	Rp-8-pCPT-cGMPS . TEA 8-pCPT-cGMPS . TEA, Rp-Isomer
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cGMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-032-M001		1 mg	230.00 USD
ALX-480-032-C100		100 µg	45.00 USD

Product Specification

FORMULA:	C₁₆H₁₅ClN₅O₆PS₂ . C₆H₁₅N
MW:	504.1 . 101.0
CAS NUMBER:	153660-04-9
PURITY:	≥99%
APPEARANCE:	White lyophilized powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. ALX-480-026).

Product Specific Literature References

(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt, et al.; Eur. J. Pharmacol. 269, 265 (1994) Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm, et al.; J. Biol. Chem. 270, 27380 (1995) Abstract; Full Text
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs; J. Neurosci. 16, 1285 (1996) Abstract

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