ALEXIS Biochemicals: 8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt

ALX-480-024

Revised 18-Jun-08

8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS	Rp-8-Br-cAMPS . Na 8-Br-cAMPS . Na, Rp-isomer
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cAMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-024-MC05		0.5 mg	95.00 USD
ALX-480-024-M001		1 mg	175.00 USD

Product Specification

FORMULA:	C₁₀H₁₀BrN₅O₅PS . Na
MW:	423.2 . 23.0
CAS NUMBER:	129735-00-8
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:	Identity determined by ¹H-NMR, MS and UV.

Product Description

Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No. ALX-480-012, and Prod. No. ALX-480-085). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No. ALX-480-007).

Product Specific Literature References

Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase: A.C. Chao, et al.; EMBO J. 13, 1065 (1994) Abstract
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture: B.T. Gjertsen, et al.; J. Biol. Chem. 270, 20599 (1995) Abstract; Full Text

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