ALEXIS Biochemicals: 8-Hydroxy-2'-deoxyguanosine

ALX-480-090

Revised 10-Jun-08

8-Hydroxy-2'-deoxyguanosine
SYNONYMS	8-OHdG
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Guanosine Derivatives Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-090-M001		1 mg	91.00 USD

Product Specification

FORMULA:	C₁₀H₁₃N₅O₅ . H₂O
MW:	283.2 . 18.0
CAS NUMBER:	88847-89-6
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (15mg/ml) or DMSO (12mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Oxidative DNA degradation product.

Product Specific Literature References

8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column: E.M. Park, et al.; PNAS 89, 3375 (1992) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol. 9, 133 (1999) Abstract
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine: K. Asagoshi, et al.; J. Biol. Chem. 275, 4956 (2000) Abstract; Full Text
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells: E. Cappelli, et al.; Biochemistry 39, 10408 (2000) Abstract
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements: M.S. Cooke, et al.; Free Radic. Res. 32, 381 (2000) Abstract

Further Categories Containing This Product:

Oxidative Stress Markers & Reagents/Related Products • DNA Repair Other Products

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