ALEXIS Biochemicals: 8-Hydroxyguanosine

ALX-480-075

Revised 14-Jun-06

8-Hydroxyguanosine
SYNONYMS	8-OHG
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Guanosine Derivatives Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-075-M001		1 mg	30.00 USD
ALX-480-075-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₁₀H₁₃N₅O₆
MW:	299.2
CAS NUMBER:	3868-31-3
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.

Product Specific Literature References

8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS 89, 11021 (1992) Abstract
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res. 413, 143 (1998) Abstract
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med. 28, 13 (2000) Abstract

Further Categories Containing This Product:

Nucleic Acid Oxidation & Alkylation / Related Products

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