ALEXIS Biochemicals: 8-iso Prostaglandin F2α

ALX-340-025

Revised 11-Jul-08

8-iso Prostaglandin F2α
SYNONYMS	8-epi Prostaglandin F₂_α 8-Isoprostane
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Prostaglandins & Prostaglandin Analogs

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-025-M001		1 mg	162.00 USD
ALX-340-025-M005		5 mg	728.00 USD

Product Specification

FORMULA:	C₂₀H₃₄O₅
MW:	354.5
CAS NUMBER:	27415-26-5
PURITY:	≥99%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	100mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in aqueous buffers (10mg/ml in PBS, pH 7.2).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years after receipt when stored at -20°C. Stock solutions in organic solvents are stable for 6 months at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

Potent vasoconstrictor in rat lung and kidney where its effects seem to be mediated through thromboxane receptors. However, evidence exists for a separate and distinct isoprostane receptor. It is also a mitogen in 3T3 cells and in vascular smooth muscle cells; may play a role in pulmonary oxygen toxicity. Thought to be formed via non-enzymatic, free-radical-induced oxidation of unsaturated fatty acids in membrane phospholipids.

Product Specific Literature References

Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells: K. Hanasaki, et al.; Biochem. Pharmacol. 40, 2535 (1990) Abstract
Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ: M. Banerjee, et al.; Am. J. Physiol. 263, H660 (1992) Abstract
Glomerular actions of a free radical-generated novel prostaglandin, 8- epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors: K. Takahashi, et al.; J. Clin. Invest. 90, 136 (1992) Abstract
Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells: M. Fukunaga, et al.; Am. J. Physiol. 264, C1619 (1993) Abstract
Role of nonenzymatically generated prostanoid, 8-iso-PGF2 alpha, in pulmonary oxygen toxicity: C.A. Vacchiano & G.E. Tempel; J. Applied Physiol. 77, 2912 (1994) Abstract
Molecular and functional evidence for the distinct nature of F2- isoprostane receptors from those of thromboxane A2: T. Yura, et al.; Adv. Prostaland. Thromb. Leukotr. 23, 237 (1995) Abstract

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