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ALX-270-282 Revised 18-Jul-07
9-Cyanopaullone
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SYNONYMS 9-Cyano-7,12-dihydroindolo-[3,2-d][1]benzazepin-6[5H]-one
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-282-M001   1 mg 70.00 USD Add To Cart
ALX-270-282-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H11N3O
MW: 273.3
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO; insoluble in water or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Very potent inhibitor of CDK1/cyclin B (IC50=25nM). Also inhibits CDK5/p25 (IC50=44nM ) and GSK-3β (IC50=10nM).
 Licensed from NCI.
Product Specific Literature References
ATP-site directed inhibitors of cyclin-dependent kinases: N. Gray, et al.; Curr. Med. Chem. 6, 859 (1999) Abstract
Fused azepinones with antitumor activity: C. Kunick; Curr. Pharm. Des. 5, 181 (1999) Abstract
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2609 (1999) Abstract
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases: D.W. Zaharevitz, et al.; Cancer Res. 59, 2566 (1999) Abstract
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition: R. Gussio, et al.; Anticancer Drug Des. 15, 53 (2000) Abstract
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity: C. Kunick, et al.; Bioorg. Med. Chem. Lett. 10, 567 (2000) Abstract
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000) Abstract
Inhibition of CDKs as a therapeutic modality: E.A. Sausville, et al.; Ann. NY Acad. Sci. 910, 207 (2000) Abstract
 
 
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