ALEXIS Biochemicals: α-Amanitin

ALX-350-270

Revised 08-Feb-08

α-Amanitin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation/Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-270-M001		1 mg	140.00 USD

Product Specification

FORMULA:	C₃₉H₅₄N₁₀O₁₄S
MW:	919.0
CAS NUMBER:	23109-05-9
MERCK INDEX:	14: 373
RTECS:	BD6195000
SOURCE/HOST:	Isolated from Amanita phalloides mushrooms.
PURITY:	≥90%
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:	Protect from light.
HAZARD:	VERY TOXIC.

Product Description

Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.

Product Specific Literature References

Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967) Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970) Abstract
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review) Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004) Abstract

Further Categories Containing This Product:

Amanitins & Phalloidins/Related Products • Protein Synthesis Other Products • RNA Polymerases/Related Products

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